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Prolonged viral replication in patients with hematologic malignancies hospitalized with COVID-19.

Garcia-Vidal, Carolina; Puerta-Alcalde, Pedro; Mateu, Aina; Cuesta-Chasco, Genoveva; Meira, Fernanda; Lopera, Carlos; Monzo, Patricia; Santos-Bravo, Marta; Duenas, Gerard; Chumbita, Mariana; Garcia-Pouton, Nicole; Gaya, Anna; Bodro, Marta; Herrera, Sabina; Mosquera, Mar; Fernandez-Aviles, Francesc; Martinez, Jose Antonio; Mensa, Josep; Gine, Eva; Marcos, Maria Angeles; Soriano, Alex.

Haematologica ; 107(7): 1731-1735, 2022 07 01.

Article in English | MEDLINE | ID: covidwho-1745156

Subject(s)

COVID-19 , Hematologic Neoplasms , Hematologic Neoplasms/complications , Hematologic Neoplasms/pathology , Hospitalization , Humans , SARS-CoV-2 , Virus Replication

Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir.

Camprubí, Daniel; Gaya, Anna; Marcos, Maria Angeles; Martí-Soler, Helena; Soriano, Alex; Mosquera, Maria Del Mar; Oliver, Aina; Santos, Marta; Muñoz, Jose; García-Vidal, Carol.

Int J Infect Dis ; 104: 379-381, 2021 Mar.

Article in English | MEDLINE | ID: covidwho-1385707

ABSTRACT

Microbiological response of SARS-CoV-2 to remdesivir in immunocompromised patients has not been evaluated. We present the case of a severely immunocompromised patient with persistent replication of SARS-CoV-2, who required different courses of remdesivir. Short courses of remdesivir might be insufficient in immunocompromised patients due to prolonged viral clearance.

Subject(s)

Adenosine Monophosphate/analogs & derivatives , Alanine/analogs & derivatives , Antiviral Agents/administration & dosage , COVID-19 Drug Treatment , SARS-CoV-2/physiology , Virus Replication/drug effects , Adenosine Monophosphate/administration & dosage , Adult , Alanine/administration & dosage , COVID-19/diagnosis , COVID-19/virology , Female , Humans , Immunocompromised Host , SARS-CoV-2/drug effects

Subject(s)

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